I have two 629's, one with a 3" and 4" barrel. When in bear country, even Yellowstone, I preferred my G20 or G29 loaded with 200 gr hardcast DoubleTap ammo @ 1300 fps.
It ain't quite a 44, but when 44's are fired from 3-4" barrels are compared to 10mm fired from the G20 the 10mm is a lot closer than most think. A lot closer. If your 629 has a 6" or longer barrel it is in another category. The G29 is over a pound lighter, almost 2" shorter overall and when loaded with G20 mags has 10 additional rounds.
The way I see it I'd need all the penetration I can get and some luck. I'm betting that 10mm load is going to equal or beat 44 in penetration and I have 10 more chances to get lucky. Like buying 16 lottery tickets instead of 6.
