I used a .300 RUM on a coastal grizzly last September. I mainly had it along for a possible goat add-on, but being that it was stainless and my .375 wasn't I ended up switching to the RUM to deal with near continuous rain. 180 Accubonds; I dare anyone to find a more instantaneously or thoroughly dead bear. Crushed it like a coyote.
On the grand scheme of things grizzlies aren't very big.