I had a load for my 270 using a stiff charge of RE22 under a 130gr TTSX. I got just over 3,200fps and was stoked to use it, but had horizontal stringing.

I tried different brands of brass, primers and seating depth, R & R'd the scope and bases, even rebedding the rifle, all to no effect.

What cured it in my rifle was H4831SC and IMR 4350, though I did lose about 50fps.