I don't shoot a lot of slugs, but I do have one in the hole often in my drillings or my Merkel combo gun when deer hunting. The Merkel shoots the Breneke @ 4" high @50 yards. Prefer them to any other slugs I've tried, but haven't tried the sabot types. I use slugs a lot in locating the center of the pattern also. When working on gun fit for shooters, I use them to determine whether they need more stock pitch or cast off, etc.
I haven't actually shot a deer with one in my combo guns, but have in shotguns with devastating results.
Just need to be sure it's legal to carry one in a shotgun only hunt. My wife's cousin in a wildlife officer in IN where it's shotguns only (though they're trying some rifle hunts this year I think) and it's illegal to use a drilling even if you have no rifle ammo. He has a Sauer drilling he would love to hunt with.
