I use it in my 45 Colt vaquero with 255 grain home cast with good results. The one that surprised me was when I loaded up some 45-70 rounds with 405 gr hard cast bullets and 12 grains of Trail Boss powder. I shot it out of my H&R Buffalo Classic, and at 50 yards, no empty 12 gauge hull was safe. The 32 inch barrel made the shot sound like "ppaff" rather than bang. My load source said velocity is 970 ft per sec. Fun stuff.
