I had a Remington 10-C Mohawk on which I installed a cantilever-style Weaver #60A base for a Browning SA-22 on the barrel and it shot pretty well, despite the crappy trigger.
The "receiver" on the Nylon 66 family is just a piece of sheet steel that covers the nylon structure and is not attached to the barrel, so experiencing a wandering zero is a common problem. The zero might not wander much, maybe not enough to bother a person who is just casually plinking at pop cans and such, but the average Nylon 66 isn't likely to be as accurate a rifles as either the average Marlin 60 series or the average Ruger 10/22 series.
