If you want peak performance and likely peak accuracy with heavy for caliber bullets in magnum handgun cartridges, then IMHO H-110/W-296 is the best powder. No it can't be downloaded, but it's the best for that use.
How do you figure that
when 2400 will give you the same energy and velocity with similar bullet weights as either of the powders you mentioned? What can those powders do that 2400 cannot?
2400 does not do that, in my experience, in any of the magnum revolver cartridges I've used it in (357, 44, 45C, 454). I've always been able to reach higher velocity with H110.
For mild to mid-range loads, Unique will give the same velocity as 2400, but with less flash and less recoil.
2400 is a popular old powder, and it meters well, but I haven't found any loads that can't be done better with either H110 or Unique. Since I'm not a guy to own just one powder, 2400 doesn't seem to have any clear advantages, in my experience.