I shoot all three (except no silly AI on the .280) and the differences seem slim. Some guys here have noted the slightly better characteristics of the 6.5 and .284 bullets at best weights. These "mid" cartridges are really versatile - I really appreciate and take advantage of that. Give me any of those, a .22/250 and a .338 Win Mag and I'm ready for any game in the US or most other places.
