Not really, and yes.
The .41 is a bit flatter shooting than the .44, about as much so as the .357.
Think of the .44 as the '06, the .357 as the .25-06, and the .41 as a .270, and you're not far off... except the .41 is harder to find components for, has less choice in componentry, and is full-house factory all-the-time.
