I use to stress and pull my hair out working with seating depth. Now a days i always start at 0.010 off the lands and i've found that i can usually find a very accurate load by juggling powder and components and just leaving the seating depth at 0.010. The only exception I've had was working with Barnes bullets which were seated 0.050 off the lands and wouldn't shoot worth a darn any closer. Works for me.
This is what I do. Usually, once the seating depth is settled , finding an accurate load is much faster.
Bob
If you are looking for the best accuracy, I don't see how settling on an arbitrary seating depth would be easier.
"Juggling powder and components" will cost more, in both dollars and time, than picking a known good powder and a common primer for the caliber being loaded and adjusting seating depth as required.
