I've done it just to see how it would work and the results weren't impressive. The two deer I shot stayed on their feet longer than any deer shot by me with 150 grain PSP from Remington or Federal. My sporterized Springfield didn't shoot them well at all nor did my Browning BAR. Both averaged about 2.5 MOA at 100 yards. Good enough for deer hunting but not what I'm used to from a bench on windless days. Plus the recoil was noticeably more rambunctious than the 150's. Glad I tried them but never again for whitetails.