I do. I,ve taken a fair amount of small game, but also several head of big game. Pronghorn, deer, elk, and moose.
I like the 41 magnum with 250grn wfngc's on the lite end or the 475L on the top end with either 375grn lfngc's or the 410wfngc.
Going to give the 454 cassull and 480 ruger a go this year.