I once shot my 22lr. at 100yds. It was fun, but rather useless for me. My best 50yd. ammo shot the best at 100yds. and my worst 50yd. ammo shot the worst at 100yds. Duh!
I'm sure if I kept testing at 100yds. with different changes in temperature that my groups would be affected by that also. Again....duh!
My rimfire shooting is pretty much aimed at Squirrels and other small game of that size. I don't shoot any Squirrels farther than about 40yds. so shooting 22lr. ammo that far is a waste of time and ammo for me. That's what my 22 mag. is for.