Placement...
Worked on a moose (.243, 100 gr). Exit wound. Penciled through. between ribs, jellied the lungs. Mostly I use a .30 or .338, on moose. They don't need it, but a brown bear might.
. I have only ever used the 100 gr. in .243. No need to f*k with very good enough!
If in doubt using an AR platform, just shoot it 10 or 20 times...