I have seen and ran a couple of 300's for elk and muleys. Most of them have ran 180 PTs. Lately the shift has occurred towards the 200 PT and ABs. Can't see much detriment to it, and the heavier 200 PT seems a little more robust than the 180 version, but me and friends would have to take another 100 animals to really tell the difference I'd bet.
Back when I was a 1 rifle guy, I decided on using just 1 bullet in the 300. That bullet was the 200gr. partition running at 2900+. It was a sledge hammer on both ends. Now days, I'd rather run a 30-06 with 200's. I see no difference in the critters reaction. Have also never caught a 200 partition, have caught 180's in the far side hides though..
