Like most on here I have shot a lot of 243 and 6mm rounds. Favorite powders were H4350, IMR4350, H4831, and H414. All have worked quite well with bullet weights from 75gr. up to 100gr. But now RL26 is the mac daddy when shooting 95gr. to 100gr. bullets. 4 rifles in 243 shooting Hornady Interlock 100gr. sp in front of 47.3 of RL26 attest to this. Velocity runs in the 3100 range with 22" barrels and accuracy is outstanding.