I personally like the .22-250 as the answer to your question. These guys make a lot of sense though. Use the .223, and if you need more than that, go with the .243. I have never been in the situation to only use one gun. I have a .22-250, but it is too heavy to pack around for coyote hunting. I have a .243 which is what i tend to ue for that now. I also have the .223, but its in the AR platform. I never know what I am going to use.