Similar to another thread, Field and Stream published an article on hunting with the 50 BMG . It didn't exactly leave me with a warm fuzzy. The following quote is from the article.

"Then there is the human element. As with any kind of long-range shooting, wind and exact distance are crucial. If you don�t know how far it is to the target, you�re sunk. On an African hunt, John had 27 misses at 1,000-plus yards and no hits. The laser rangefinder he and Wendy were using would not reflect off an animal at those extreme distances."