I took my first brown bear with a 375 and both a 300 A-Frame and a 300 GameKing. Both bored without difficulty, broadside through the shoulder area. 124 yards.
A second browny was taken with a 358 Winchester and 250 Hornady SPs. 100 +/- yards.
The most recent with a 350 NorthFork in 45-70. 246 yards.
I would/will use a 220 Partition in a 30-06 without hesitation.