Several years ago I built a 378 Weatherby to take to Africa. It was built on a Defiance Ultralight action with a 23" Muller #4 barrel in a Mcmillan Mountain Rifle stock with magnum fill and a small single side-port muzzle brake. If I recall correctly, it was 7lb 9oz before adding a 1-8 Swarovski.
Leading up to the trip, I spent a range session doing load development where I fired 40+ rounds ranging from 235gr at 3280 to 300gr at 2975.
While my shoulder took a beating, the worst part was the concussion; I swear I had a headache for two straight days afterwards.
A friend ended up killing a cape buffalo with it using a 270gr Barnes LRX. I would NOT recommend the bullet for buffalo at 40yrs given the muzzle velocity of 3118fps as they badly deformed on the shoulder bones and did not penetrate in even a remotely straight line.
