In a standard 280 Remington 1st edition mountain rifle I'm using 59.0grs of H4350 to push 120gr Nosler Ballistic tips to a chronographed 3183 fps with excellent accuracy. This 22" skinny barrel has never produced astounding speeds, but this load is fast enough and when paired with excellent accuracy is good enough for deer or predators. I've read reports where other hunters used newer 120gr BT's on elk with excellent success, however I'd probably prefer something bigger for elk. For normal hunting I'll echo what others have said to say that the 280 Remington is about as good as it gets. The load above is from the Hodgdon 2020 annual manual developed for the 120gr Bar TSX. I substituted the 120gr Nosler BT and experienced no high pressure indicators. As always, use caution and start lower.