Years back, I used Sierras because they shot a little more accurately from my rifle. I killed moose with them, and I usually am hesitant to say a bullet failed if I eat the animal it killed. I did notice that I was not getting complete penetration from the Sierras, and I was also not recovering any bullets. I switched to Hornady 165 BTSP IL and was running them out the tube at 2892 fps. Still getting dead moose, but I was finding the bullets nicely expanded near the far side of the moose.
For deer, and maybe elk, I would recommend highly, that you find a load that works well in your rifle with the interlock bullets -- 165 variety -- around 2800 - 2900 fps. Mine liked a stiff load of IMR4350, but I'm guessing that H414 would do as well.
