Being lefty, my experience is with the Kimber of OR and the Belgian T-Bolt so I cannot offer first hand advice on the two you mention. But I support your interest in a high end .22lr--they are one of life's joys. The 541S is one heck of a shooter that you ought to consider as well. You are also starting to get into the price range for an Anschutz.
So I guess I tend to favor the somewhat older ones as opposed to recent manufacture. The nice thing about .22lr is it is relatively rare to see them with trashed barrels. Part of the reason I like the older ones may be the triggers--they seem to be less lawyered up.
