I shot my lion at around 30 paces with a 375 H&H as he tried to sneak in to steal meat from a buff kill. The speed with which the pride male covered the football field distance to whip the old outcast male away was startling... I have no doubt that a 300 magnum with a premium bullet would be effective on undisturbed lion from a hide. However I would highly recommend hunting with a caliber capable of stopping a lion charge. Even if your single shot is sucessful from a blind you still may have to protect youself from lioness. Lions scare me...