Tide,
I have not seen near the animals harvested as Ray has but in the case of the 6MM and the 85 TSX I have seen first hand the performance of that round and bullet. The rifle is an Ackley version and that bullet combination works real well on a Whitetail and did a fine job on a Wyoming Antelope a month ago. No recovery, pass through, no blood trail (they died where they stood).
Don't know what would happen if a guy took a less than desirable shot but my suspicion is that this combination would work as well as anything considered practical.

Dave