It's probably doable. It would need chambering, and a firing pin engineered and built into the breech plug. I have no idea what the forward surface of the breech plug looks like. It would have to be flat and fit snugly against ones cartridge. As long as one stayed with black powder, contained pressure should be identical to its present loads.
I'd do some remote test firing though before bedding down on the bench with it.
One would have more WOW factor though by simply purchasing a spiffy Shiloh Sharps.
