The one thing that hasn't been mentioned so far regarding twist, and why slower twists work better in larger calibers is because twist affects the surface speed. If you spin a .35 caliber bullet in a 1:10 at the same velocity as a .25 caliber through a 1:10, the outside diameter of the .35 will be spinning much faster than the .25 The center of the bullet will be spinning at the same rpm, but not the outside of the bullet.
So that's why it takes such a fast twist in .22 calibers to stabilize bullets with a lower sectional density, length, or BC than a .25 cal of the same weight.
Make sense?
And, no I'm not a ballistic engineer. If I was, then the term for "outside diameter speed" would have come to me, but it didn't.
