I believe with the Barnes TSX and the 338 Win Mag you can safely kill anything in North America with the Barnes 210 TSX. You may want to read some of Coni Brooks' hunting adventures with the 185 TSX. She has had remarkable success globally using the 185 TSX. Both the 210 or 185 TSX have remarkable terminal effect if placed in the right area. Personally, I've had good luck using H4350/72.0 with WLRM primers and seating the 210 TSX bullet somewhere between .040 and .050 off the lands.