The 280 Rem does have a slightly longer head space dimension than the 270, 25-06, and 30-06.
A wildcat 6.5-280 would gain you the capacity for a couple extra kernels of your favorite slow burning extruded powder. While the wildcat 6.5-280AI could net you a couple grains of capacity compared to the 6.5-06.
Neither will quite match the internal capacity of the Gibbs cartridge.