I've had/have a rather good herd of 22-250AI's and they run the gamut in twist/length/contour,etc...as I've long been hip on the chambering(going back to the pre-LRF Days).

In broad brushstrokes,as case capacity is increased,in relation to bore size the more fickle the diameter becomes. It is simply easier to eek lower ES/SD's,in the milder mannered offerings,though few are a bigger fan of speed than I.

The 75A-Max with single digit SD,will slip conditions rather nicely and do amazing things downrange,when scooted from a modest length 223AI....................