Jared Schmidt killed a small buck with his Les Baer and a 230 grain speer gold dot loaded to Plus P. The wound channel and organ distruction was indistinguishable from similar shots with 44 magnums. JD Jones put several hardballs into a hog. One hit a heavy shoulder bone and bounced out but the others reached vital structurs and killed the hog.
"Deer often run even when shot through the lungs with a rifle. Bullet holes through both lungs is fatal. The only sure instant death is with a CNS hit."
This is completely true. There is an element of luck even with the most carefully placed shots. much of the talk about what is an adequate hunting load is just self-stimulation by windbags.