I fell in love with the 375 win when they first came out, had one built with a 24in med weight barrel. With the 250gr power points it performed exceptionally, every bullet recovered looked like an advertisement for the bullet. Used the 220 hornady with 39gr of reloader 7, okay accuracy but the bullets came apart. Shot deer, moose, black and brown bear with it. After they dropped the 250 power point couldn't find a bullet I was satisfied with. I would look into hawk or kodiak bullets and see if either company makes a 250, more accurate due to twist rate and this caliber is best with a heavy bullet in my opinion, barnes used to make a 250, don't know it they still do. Definetly a great rifle/caliber combination. Moved to 356win nest, great results with the 220 speer and the 250 kodiak, the 250 power points didn't open up on deer in 356.