I'm sure on a broadside shot where you could drop it in the heart lung area, they would be deadly. I use the 120 TSX in my 6.5s as it will shoot under 1" and get full penetration even on quartering or facing shots. Two Antelope and 3 Deer were dropped with one shot from 60 to 325 yards, only one was a classic broadside shot. "Over" LOL, penetration in all cases, no bullets recovered.
Have shot a few Yotes with the 100 6.5 NBT and it really wrecks them but does come apart with great violence.
