I have a Ruger Old Vaquero Stainless 44 Mag with5.5" barrel and have loaded 300 grain cast slugs with 21.5 of W296 for 1372 fps through a chronograph. Plenty of poop and plenty of recoil!!!

Also pushed 240 grain cast over 24.1 grains of W296 for a velocity that was up there but have lost the data.

Both loads were accurate for about 6 shots and then the recoil accumulation began to be a factor for me.