My 22/250 is also my favorite rifle here in NW Ohio; you will do fine with that at long range as well. I use the Sierra 40 gr.HP and Speer 52 HP as both are great groundhog killers.
And, both of those bullets work great in my .223! Also, the Hornady SX and Sierra Blitz in 50 gr. work well in my .222 and .223.
The Hornady Vmax is well liked by many, but they are a bit too frangible sometimes on large groundhogs or less than ideal shots e.g. through some grass/weeds partially obscuring the target. They seem to spash on neck shots, especially with the 22/250.
Due to areas I hunt, I don't shoot my 25/06 much for groundhogs anymore (used to when I first got it).
Last edited by BuckeyeSpecial; 06/14/11.
