Just a thought.....Have you chrono'ed any factory rounds in comparison? From what I remember most factory 300WM 180gr run 3150-3250. This may help determine weather you really have a barrel/chamber problem or if you need to choose a slower burning powder, which would normally give lower pressures in longer barrels.
Good point. I can't say I have. Part of the reason is, the thing shows high pressure signs so early with handloads, I'm afraid to torch the Weatherby stuff off in it. I guess I should have mentioned this in my original post, but I'm getting high pressure signs a grain or two above book minimum loads.
Also, $80 a box seems like an expensive experiment.
I'd be a bit surprised if my powders are too quick though; IMR 7828 and H1000 are the ones I've tried. They work great in my 7STW, so I just assumed they'd be good for the Weatherby as well.