As far as barrel life I don't know but it is directly correlated to the volume of powder and pressure. On my 270 wsm I load it like it is a 270 AI and suspect I will get at least 2,000 rounds. That's way more than a 6.5 x 284 but most are loaded really hot by the 1000 yd bench crowd.
Loads in the 63-65,000 psi range will generate more heat and wear and it increase with each step down in bore diameter.
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