I've used 300 grain "X" bullets on Brown Bear in Alaska and out of four solid hits, recovered only one bullet. That one struck the bear on the left shoulder, traversed the body and was recovered under the skin on the outside of the right hip.

I've always preferred "heavy for caliber" bullets and decided to change things up a bit for my first (upcoming) trip to Africa. Although I'll use my same .375 H&H rifle for buffalo, this time I'll be bring 350 grain Woodleigh Weldcore softpoints and solids. While the velocity is somewhat reduced (compared to the PMC loaded Barnes "X" bullets), I've read a lot of good things about these heavier rounds and their effects on buffalo. They aren't inexpensive, but neither is the trip (or my hide)!