Long time IMR 4350 user here. I made the switch to H a while back and use it extensively in the 30-06 and 300 wizzum with excellent results. I have noticed a difference in poi and velocities when using the IMR as compared to the H. The H4350 doesn't waiver. However the IMR4350 isn't really that bad but nonetheless it is noticable. I'd go H4350 since it meters better and is less temp sensitive. Groups with 300 wizzum:

10 shot group:
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5 shot group:
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Groups shot with ol 30-06 using H4350 and different bullet types:
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El cheapo winchester power points (180 gr.)
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Both are great powders and to be honest IMR4350 has always been my favorite but I honestly think H4350 has it beat......

Originally Posted by raybass
I try to stick with the basics, they do so well. Nothing fancy mind you, just plain jane will get it done with style.
Originally Posted by Pharmseller
You want to see an animal drop right now? Shoot him in the ear hole.

BSA MAGA