I have not tried bullets over 300 grains but don't really see the need. Even a hollowpoint 240 grain bullet will bust right through a deer and leave two large holes.
My Marlin likes 240g. Montano Gold either HP or SP with Hornaday XTP next and Speer FP and Remington SJHP pretty close. At 100 yards 3" is pretty common with open sights.
http://www.grovestreet.com/jsp/onepic.jsp?id=1066975
