With my .300 Win out of a Ruger 77, shooting 180 gr NP's, the velocity difference between identical weights of an old lot of MRP and a much newer lot of RL-22 is running usually 25fps or less. This is about what I would expect from normal lot-to-lot variations with any powder.
I don't remember the exact charge weight, but it's around 74.0gr, well below the max shown by Alliant for a 180gr Speer Spitzer and what Norma shows for a 180gr NP or Oryx. The load reliably chronos a little above 3000fps out of my rifle. Also, both max loads shown on both Alliant for RL-22 and Norma for MRP are almost identical for similar bullets.
Like HunterJim, N205 used to be my powder of choice for that rifle.
Last edited by Skeezix; 05/25/12. Reason: correct error