I have been shooting the 300 Win Mag for many years, never had any success with the 4350's. The speed they list in the Nosler #6 might be attainable but for me the S.D. and E.S. were way too high and the accuracy was not there.
They did get one thing right by saying RL22 was the most accurate powder tested with 180's and H1000 with the 210-220.

To me it is a bit of a joke how they do the reloading book anyway. For example take the 6ppc they list 10 different powders, 8 of the 10 not a person on the planet would use in this cartridge and they leave out the 1 powder that 90% of people use N133.