To me, the fun of spot and stalk hunting is seeing how close you can get, not how far you can shoot from.
Antelope can be spooky and I too have seen them take off running at the mere sight of a hunter near a mile away in a pickup. I have also seen them stand there 50 yards from a road without a care in the world. I'd bet a fair sum of money to say that most of them are shot at less than 300 yards, certainly within 400 yards. Even at their spooky-est (technical term) I haven't found myself ever unable to get within 400yards, most of the time much closer than that.
Archery hunting I have gotten as close as 50 yards, which for me and my recurve is too far. The first goat I shot was from about 75 with a .30-06. Last one I shot was from about 250 out with a 7mm Rem Mag.
Around here those who do use different guns for Antelope the .25-06 is way out front of the others then probably the .243 Win and .22-250.
Like I said before the .25-06 is all you need to do the job and more in a long action.
