I'm thinking of rebarreling my 22-250 to 6XC this spring. I shoot prairie dogs out in Utah in the winter when there is nothing else to shoot. The places I go there are not big colonies, just scattered dens. Most of the shooting is 300 to 700, or more. Ranges get too long in the always present breeze for the 52 gr bullets I shoot from my 14 twist barrel.
I had thought to go with another 22-250 and a fast twist barrel, but I want to be able to shoot the Berger Hunting VLD's. They have been working really well for me this year in 7mm, on 'chucks out to 1100+ yards.