The 45 colt with modern brass, heavy cast bullets and large doses of 296 powder will make meat all day long. I have 3 .45 colts a Ruger B/H w/7 1/2" barrel, and 2 94 Winchesters one with a 20" barrel and the other with 24" barrel. With well placed shots any deer within a 150 yards gets an invitation to many dinners at my house.