I have only used the 300 SAF on buffalo. I also used a solid from a 375 and it did not strike me afterwards as the right bullet for the caliber.
I have recently turned to the 270 TSX but I have not used it on buffalo. I have used it up to lion and gembsbok and through in an elk because I fell in love with the caliber, bullet combo. Im not sure you would have what they refer to as over penatration. I like penatration in a DG gun. I understand the herd situation but 1) I enjoy hunting small groups of bulls and 2) I don't shoot if something is behind something. I enjoy the tracking as much as the shooting so this is what drives me.
Also on the 270 TSX one of my scope set ups uses a Z6 with a TDS reticle. I have made 400 plus yard shots on springbuck and never felt limited at all