I have been using the HM-2 for a few years in a Kimber Pro Varmint.I always try to take shots behind the shoulder thru the lungs. The HM-2 is a sure killer but seems to cause more "shock" than a HV .22 HP. This seems to make the squirrel spasm and its claws grab the tree and hang on rather then fall. When sitting on a large limb this gives the impression of a missed shot.I think this is a great round but for gray squirrel's but a .22 Winchester Power Point is still a better round for the job. I have also used CCI Subsonic HP's with pretty good success. The HM-2 could use a 20grn. HP to improve itself as a gray squirrel round. Just my 2 cents