I like heavy for caliber bullets, and I don't think you can have too much gun. I've shot black bears with .375 H&H and .458 Lott. As far as the .30-06 Springfield, I think the 180 grain bullet is perfect, versatile, and particularly suited for tough game like African antelope. It will be ideal for wildebeest, kudu, oryx, and zebra. I favor more controlled expansion than a ballistic tip, however. Partition, A-Frame, TSX, even a Scirocco would be a reasonable choice.