Have shot the Lee bullet a lot as you have suggested unsized, but I used a different lube, 50-50 mix of bees wax and Tkompson bore butter and some what softer than the #2 alloy. achieved good to excellent accuracy in a Marlin Cowboy and a H&R Target with the following.
AA5744 19.0 CCI250 vel 1380 some unburned powder. Best in H&R.
RL7 24.0 CCI200 vel. 1701 Best in Marlin
Unique 10.0 CCI200 vel.1287 good accy. not in excellent category. Improved if powder settled to bottom of case.
Full case of Swiss 1 1/2 pre compressed .020 card wad CCI250 H&R
Pyrodex RS & or Select 50.0 measured not weighed .020 card wad
pre compressed approx. 1/8 inch. H&R.
RL7 proved to be best powder on average with both cast and jacketed bullets under 300 gr. in my rifles.