My quickest response time isn't known as we've never timed it but we've had more than a handfull of quick ones. We've had way more that seemed to take forever!
The quickest for me was one where I sat down got mu pistol up on my knee to wait. About the time I felt like I was sitting well I saw a pair of coyotes watching me a little over 100 yards out. Rather than wait for my father to start calling, I cocked the Contender and smoked one. He came running up the hill thinking I'd had an accident! That was my first yote with the Contender, farthest I ever got with it. It was a .223 barrel with a 2.5x scope.
My closest was so close many wouldn't believe it, so I had my Dad take a picture of it. It's in his book.

“You never need fear a man, no matter what his size. When danger threatens, call on me, and I will equalize.”
Samuel Colt.

�Common sense is genius dressed up in work clothes.� - Ralph Waldo Emerson